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Ahead of Print -Severe Fever with Thrombocytopenia Syndrome Virus, South Korea, 2013 - Volume 20, Number 11—November 2014 - Emerging Infectious Disease journal - CDC

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Ahead of Print -Severe Fever with Thrombocytopenia Syndrome Virus, South Korea, 2013 - Volume 20, Number 11—November 2014 - Emerging Infectious Disease journal - CDC



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Volume 20, Number 11—November 2014

Dispatch

Severe Fever with Thrombocytopenia Syndrome Virus, South Korea, 2013

Sun-Whan Park, Myung-Guk Han, Seok-Min Yun, Chan Park, Won-Ja Lee, and Jungsang RyouComments to Author 
Author affiliations: Korea Centers for Disease Control and Prevention, Cheongwon-gun, South Korea

Abstract

During 2013, severe fever with thrombocytopenia syndrome was diagnosed in 35 persons in South Korea. Environmental temperature probably affected the monthly and regional distribution of case-patients within the country. Phylogenetic analysis indicated that the isolates from Korea were closely related to isolates from China and Japan.
Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease. Symptoms and laboratory abnormalities are fever, thrombocytopenia, leukocytopenia, and elevated serum enzyme levels. Multiorgan failure occurs in severe cases, and 6%–30% of case-patients die. The syndrome is caused by the SFTS virus (SFTSV) (genus Phlebovirus, family Bunyaviridae). SFTS case-patients were first reported in China (1) and more recently were reported in Japan (2) and South Korea (3). Two case-patients with symptoms consistent with a similar virus, Heartland virus, were reported in the United States (4).
Ixodid tick species are implicated as vectors of SFTSV (1,5,6). One study described a SFTSV prevalence in Haemaphysalis longicornis ticks, a major vector of SFTSV, of 0.46% minimum infection rate in South Korea (7); in another study, SFTSV was detected in ticks that had bitten humans (6). From these studies, we realized that SFTSV was common throughout the country. We aimed to evaluate the prevalence of SFTS in South Korea and isolate the SFTSV to analyze its phylogenetic properties.
Thumbnail of Isolation of severe fever with thrombocytopenia syndrome virus (SFTSV) from case-patients, South Korea, 2013. A) Indirect immunofluorescent features of Vero E6 cells primed with SFTSV N protein monoclonal antibody and reacted with fluoresce in isothiocyanate-conjugated anti-mouse IgG. B) A transmission electron microscopy image of Vero E6 cells infected with SFTSV. Scale bar indicates 500 nm. C and D) Phylogenetic analysis of SFTSV Korea isolates based on the partial medium (M) and
Figure 1. Isolation of severe fever with thrombocytopenia syndrome virus (SFTSV) from case-patients, South Korea, 2013. A) Indirect immunofluorescent features of Vero E6 cells primed with SFTSV N protein monoclonal antibody and reacted...

Dr. Sun-Whan Park is a senior researcher at the Division of Arboviruses, National Institute of Health, Korea Centers for Disease Control and Prevention. His research focuses on bunyaviruses, including SFTSV and hantavirus.

Acknowledgments

We thank all involved in SFTS diagnosis in 2013, especially the staff in 17 regional Institutes of Health and Environment. We also thank Young Eui Jeong and Ki Ju Choi for technical support with molecular evolution and the electron microscope.
This study was financially supported by the Korea National Institute of Health, Korea Centers for Disease Control and Prevention (program no. ******************** and 4800-4861-304-210-13 [grant no. 2014-NG53002-00]).

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Figures

Suggested citation for this article: Park S-W, Han M-G, Yun S-M, Park C, Lee W-J, Ryou J. Severe fever with thrombocytopenia syndrome virus, South Korea, 2013. Emerg Infect Dis [Internet]. 2014 Nov [date cited]. http://dx.doi.org/10.3201/eid2011.140888
DOI: 10.3201/eid2011.140888

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