domingo, 5 de julio de 2015

A Novel Botulinum Toxin, Previously Reported as Serotype H, has a Hybrid Structure of Known Serotypes A and F that is Neutralized with Serotype A A... - PubMed - NCBI

A Novel Botulinum Toxin, Previously Reported as Serotype H, has a Hybrid Structure of Known Serotypes A and F that is Neutralized with Serotype A A... - PubMed - NCBI



 2015 Jun 10. pii: jiv327. [Epub ahead of print]

A Novel Botulinum Toxin, Previously Reported as Serotype H, has a Hybrid Structure of Known Serotypes A and F that is Neutralized with Serotype A Antitoxin.

Abstract

Botulism is a potentially fatal paralytic disease caused by the action of botulinum neurotoxin (BoNT) on nerve cells. There are 7 known serotypes (A through G) of BoNT and up to 40 genetic variants. Clostridium botulinum strain IBCA10-7060 was recently reported to produce BoNT serotype B (BoNT/B) and a novel BoNT, designated by the authors as BoNT/H. The botulinum neurotoxin gene (bont) sequence of BoNT/H was analyzed against known related bont sequences. Genetic analysis suggested that BoNT/H has a hybrid-like structure containing regions of similarity to BoNT/A1 and /F5. This novel BoNT was serologically characterized by the mouse neutralization assay and a neuronal cell-based assay. The toxic effects of this hybrid-like BoNT were completely eliminated by existing serotype A antitoxin including those contained in multivalent therapeutic antitoxin products that are the mainstay for human botulism treatment.
Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

PMID:
 
26068781
 
[PubMed - as supplied by publisher]

No hay comentarios:

Publicar un comentario