Enterovirus A71 Meningoencephalitis Outbreak, Rostov-on-Don, Russia, 2013 - Volume 21, Number 8—August 2015 - Emerging Infectious Disease journal - CDC

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Enterovirus A71 Meningoencephalitis Outbreak, Rostov-on-Don, Russia, 2013 - Volume 21, Number 8—August 2015 - Emerging Infectious Disease journal - CDC

Volume 21, Number 8—August 2015

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Enterovirus A71 Meningoencephalitis Outbreak, Rostov-on-Don, Russia, 2013

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• The Study
• Conclusions
• Suggested Citation

Figures

• Figure 1
• Figure 2

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Ludmila V. Akhmadishina, Marina V. Govorukhina, Evgeniy V. Kovalev, Svetlana A. Nenadskaya, Olga E. Ivanova, and Alexander N. Lukashev 

Author affiliations: Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia (L.V. Akhmadishina, O.E. Ivanova, A.N. Lukashev); Center of Hygiene and Epidemiology of Rostov Region, Rostov-on-Don, Russia (M.V. Govorukhina); Administration of Russian Federal Consumer Rights Protection and Human Health Control Service of Rostov Region, Rostov-on-Don (E.V. Kovalev, S.A. Nenadskaya)

Suggested citation for this article

Abstract

Seventy-eight cases of enterovirus infection, including 25 neuroinfections, occurred in Rostov-on-Don, Russia, during May–June 2013. The outbreak was caused by an enterovirus A type 71 (EV-A71) subgenotype C4 lineage that spread to neighboring countries from China ≈3 years earlier. Enterovirus associated neuroinfection may emerge in areas with a preceding background circulation of EV-A71 with apparently asymptomatic infection.

Enterovirus A type 71 (EV-A71; family Picornaviridae, genus Enterovirus, species Enterovirus A) is the most neuropathogenic nonpolio enterovirus in humans. Over the past 30 years, this virus has caused many outbreaks and epidemics of hand, foot and mouth disease (HFMD) with neurologic complications in the Asia-Pacific region and China (1). In Europe, EV-A71 commonly causes asymptomatic infection (2–4) and is only occasionally associated with severe neuroinfection (3,5). The last epidemics of EV-A71 infection in Europe occurred during 1975–1978 (6,7).

Dr. Akhmadishina is a postdoctoral researcher. In 2013 she completed a PhD thesis on molecular epidemiology and seroepidemiology of EV-A71 in Russia.

Acknowledgment

This study received core funding from the participating institutions and from a Russian scientific foundation grant (no. 14-15-00619 to A.N.L. and L.V.A.).

References

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Figures

• Figure 1. Incidence of neuroinfection during an enterovirus A type 71infection outbreak among children attending a childcare facility, Rostov-on-Don, Russia, 2013. Of 78 infected children (1–7 years of age), 25 experienced...
• Figure 2. Phylogenetic tree comparing sequences of outbreak and other enterovirus A type 71 (EV-A71) subgenogroup C4 strains isolated in Russia during 2012–2013 with the most closely related sequences in GenBank....

Suggested citation for this article: Akhmadishina LV, Govorukhina MV, Kovalev EV, Nenadskaya SA, Ivanova OE, Lukashev AN. Enterovirus A71 meningoencephalitis outbreak, Rostov-on-Don, Russia, 2013. Emerg Infect Dis. 2015 Aug [date cited]. http://dx.doi.org/10.3201/eid2108.141084

DOI: 10.3201/eid2108.141084